Meindl P, Bodo G, Tuppy H
Arzneimittelforschung. 1976;26(3):312-6.
Among the aminoacyl derivatives of 2,7-diaminofluoren-9-one a few compounds were found capable of inducing interferon in the mouse when administered perorally. One of them, 2,7-bis[(diethylamino)acetylamino]fluoren-9-one exhibited an inducing activity comparable to that of 2,7-bis-(2-diethylaminoethoxy)-fluoren-9-one (tilorone). The synthesis of derivatives of fluorene, fluorenol, fluorenone, diaminobenzophenone, diaminiodiphenylmethane and benzidine, all of them with corresponding side chains, allowed to establish structural requirements for interferon inducing capability.
在2,7-二氨基芴-9-酮的氨酰基衍生物中，发现有几种化合物经口服给药后能够在小鼠体内诱导干扰素。其中之一，2,7-双[（二乙氨基）乙酰氨基]芴-9-酮表现出与2,7-双（2-二乙氨基乙氧基）芴-9-酮（泰洛龙）相当的诱导活性。芴、芴醇、芴酮、二氨基二苯甲酮、二氨基二苯基甲烷和联苯胺的衍生物的合成，所有这些衍生物都带有相应的侧链，从而得以确定干扰素诱导能力的结构要求。
