A simple electronic circuit for simulation of pharmacokinetic processes.

A simple electronic circuit is constructed for simulation of the theoretical curves associated with single and multiple dosing kinetics. The output is an analog device which generates plasma concentration curves versus time, consistent with the assumption in a one-compartment open model with rapid intravenous injection or first-order absorption. Potentiometer settings offer variations in dosing schedules, distribution volumes as well as in absorption and elimination rate constants. All details are made from standard electronic components. The device can be used in teaching of the elements of pharmacokinetics.