Knall C, Johnson G L
Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA.
J Cell Biochem Suppl. 1998;30-31:137-46.
Complex cellular responses involve the integration of heterotrimeric G protein systems with protein kinase signal transduction pathways. Key in this integration is the control of small GTP-binding proteins including Ras and Rho family members. In this paper, we discuss the control of signal transduction pathways by G proteins and their integration with specific tyrosine kinases. The integration of G proteins, kinases, and small GTP-binding proteins in controlling cellular responses is illustrated through the newly defined G alpha 12/13-regulated pathways. Furthermore, the polymorphonuclear leukocyte provides a primary cell system for analyzing the integration of G proteins, kinases, and small GTP-binding proteins in controlling cellular functions such as superoxide production, adherence, chemotaxis, and granule secretion.
复杂的细胞反应涉及异源三聚体G蛋白系统与蛋白激酶信号转导途径的整合。这种整合的关键在于对包括Ras和Rho家族成员在内的小GTP结合蛋白的控制。在本文中，我们讨论了G蛋白对信号转导途径的控制及其与特定酪氨酸激酶的整合。通过新定义的Gα12/13调节途径说明了G蛋白、激酶和小GTP结合蛋白在控制细胞反应中的整合。此外，多形核白细胞为分析G蛋白、激酶和小GTP结合蛋白在控制细胞功能（如超氧化物产生、黏附、趋化性和颗粒分泌）中的整合提供了一个主要细胞系统。
