Tomita H, Fuse S, Ikeda K, Matsuda K, Chiba S
Department of Pediatrics, Sapporo Medical University School of Medicine, Japan.
Acta Paediatr Jpn. 1998 Dec;40(6):608-11. doi: 10.1111/j.1442-200x.1998.tb02000.x.
We report a 3-month-old girl with Costello syndrome complicating fatal hypertrophic obstructive cardiomyopathy. She had typical findings of this syndrome, slight dyspnea and persistent wheezing. Doppler echocardiography revealed asymmetric septal hypertrophy and systolic anterior movement of the anterior mitral leaflet. There was grade 1 mitral regurgitation. Although once her heart failure had been controlled medically, she died suddenly following deterioration of her heart condition. Costello syndrome can complicate fatal hypertrophic obstructive cardiomyopathy.
我们报告了一名3个月大患有科斯特洛综合征并并发致命性肥厚性梗阻性心肌病的女孩。她有该综合征的典型表现，轻微呼吸困难和持续性喘息。多普勒超声心动图显示不对称性室间隔肥厚以及二尖瓣前叶收缩期向前运动。存在1级二尖瓣反流。尽管她的心力衰竭曾通过药物得到控制，但在心脏状况恶化后突然死亡。科斯特洛综合征可并发致命性肥厚性梗阻性心肌病。
