Ching N P, Lumeng J, Pang R, Pang G, Or F W, Ching N W, Ching C
Department of Surgery, John A Burns School of Medicine, St. Francis Medical Center University of Hawaii, Honolulu, USA.
Hawaii Med J. 1998 Dec;57(12):735-9.
The antiviral and immunomodulatory effects of interferon were assessed in the treatment of chronic Hepatitis C in multi-ethnic patients to prevent viral replication and chronic liver damage. Three million units of recombinant interferon alpha-2b were administered three times a week for 48 weeks to a group of 9 active Hepatitis C patients. A clinical response was defined as normalization of serum ALT values. Serum was frozen and stored for Hepatitis C viral assays. Four patients normalized their liver functions. When viral levels were measured only two patients had unmeasurable levels of HCV RNA after treatment. Therapeutic results were observed and much work needs to be done to improve therapy because a serious epidemic is predicted for the future.
在多民族慢性丙型肝炎患者中评估了干扰素的抗病毒和免疫调节作用，以预防病毒复制和慢性肝损伤。给一组9例活动性丙型肝炎患者每周3次、每次给予300万单位重组干扰素α-2b，共治疗48周。临床反应定义为血清ALT值恢复正常。血清冷冻保存用于丙型肝炎病毒检测。4例患者肝功能恢复正常。治疗后仅2例患者检测不到HCV RNA病毒水平。观察到了治疗效果，但由于预计未来会有严重的疫情，仍有许多工作需要做以改进治疗方法。
