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关键全在于参数:对一些关于低强度激光疗法的著名阴性研究的批判性分析。

It's all in the parameters: a critical analysis of some well-known negative studies on low-level laser therapy.

作者信息

Tunér J, Hode L

机构信息

Swedish Laser Medical Society, Stockholm, Sweden.

出版信息

J Clin Laser Med Surg. 1998 Oct;16(5):245-8.

PMID:9893504
Abstract

OBJECTIVE

Scientific studies include references to historical studies on low-level laser therapy (LLLT) in general and to old studies on the specific subject in particular. Some studies are quoted often. It is fair to take a second look at these, since few people seem to have read them carefully, and others have read them only in the abstract form. This paper critically reviews the parameter pitfalls found in many of the classic "negative" studies.

SUMMARY BACKGROUND DATA

A study of 1,200 papers on LLLT has resulted in 85 positive and 35 negative double-blind studies. The negative studies have been scrutinized carefully in an effort to pinpoint possible reasons for the failures. In the following, the majority are double-blind studies, but some non-blinded and animal studies have been included to give typical examples of pitfalls.

摘要

目的

科学研究通常会提及关于低强度激光疗法(LLLT)的历史研究,特别是关于该特定主题的旧研究。有些研究经常被引用。重新审视这些研究是合理的,因为似乎很少有人仔细阅读过它们,而其他人只是以摘要形式阅读过。本文批判性地回顾了许多经典“阴性”研究中发现的参数缺陷。

总结背景数据

对1200篇关于LLLT的论文进行研究后,得到了85项阳性和35项阴性双盲研究。对阴性研究进行了仔细审查,以找出失败的可能原因。以下内容中,大多数是双盲研究,但也纳入了一些非盲法和动物研究,以给出缺陷的典型例子。

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