Shlosberg A, Ershov E, Bellaiche M, Hanji V, Weisman Y, Soback S
Kimron Veterinary Institute, Bet Dagan, Israel.
Drug Metabol Drug Interact. 1997;14(2):109-22. doi: 10.1515/dmdi.1997.14.2.109.
The fluoroquinolone antimicrobials norfloxacin and enrofloxacin were found to inhibit hepatic microsomal cytochrome P-450 monooxygenases in the livers of broiler chickens using dosages as given in commercial flocks. Norfloxacin inhibited the process of N-demethylation of aminopyrine to a greater degree, while enrofloxacin more markedly inhibited hydroxylation of aniline.
研究发现，使用商业鸡群中的给药剂量时，氟喹诺酮类抗菌药物诺氟沙星和恩诺沙星会抑制肉鸡肝脏中的肝微粒体细胞色素P - 450单加氧酶。诺氟沙星对氨基比林的N - 去甲基化过程抑制作用更强，而恩诺沙星对苯胺羟基化的抑制作用更显著。
