Weiner P, Konson N, Sternberg A, Zamir D, Fireman Z
Department of Medicine A, Hillel Yaffe Medical Center, Hadera, Israel.
Respir Med. 1998 Aug;92(8):1071-5. doi: 10.1016/s0954-6111(98)90357-2.
Exercise-induced bronchoconstriction (EIB) occurs in the majority of patients with asthma. The relationship between asthma and gastro-oesophageal reflux (GER) is well defined, and the reports of exertional gastro-oesophageal acid reflux in healthy subjects, prompted us to study the relationship between EIB and GER. Following an overnight fast and medication withholding, 15 asthmatics and 15 normal subjects were placed on continuous monitoring of oesophageal pH and ECG. After baseline monitoring of oesophageal pH, at rest, for 30 min, spirometry was performed. Thereafter, the subjects underwent rigorous treadmill exercise for 8 min followed by spirometry, 10 min after running. Twelve out of 15 asthmatics and none in the control group demonstrated significant fall in FEV1 in response to exercise. However, only six out of 15 normal subjects and three in the asthmatic group had evidence of GER during or following exercise. We concluded that there is no significant correlation between EIB and GER in patients with asthma.
运动诱发的支气管收缩（EIB）在大多数哮喘患者中都会发生。哮喘与胃食管反流（GER）之间的关系已明确，而健康受试者运动性胃食管酸反流的报告促使我们研究EIB与GER之间的关系。经过一夜禁食并停用药物后，对15名哮喘患者和15名正常受试者进行食管pH值和心电图的连续监测。在静息状态下对食管pH值进行30分钟的基线监测后，进行肺功能测定。此后，受试者进行8分钟的严格跑步机运动，跑步后10分钟再次进行肺功能测定。15名哮喘患者中有12名，而对照组中无人在运动后出现FEV1显著下降。然而，15名正常受试者中只有6名以及哮喘组中有3名在运动期间或运动后有GER的证据。我们得出结论，哮喘患者中EIB与GER之间无显著相关性。
