Lavoinne A, Meisse D, Quillard M, Husson A, Renouf S, Yassad A
Groupe de Biochimie et Physiopathologie Digestive et Nutritionnelle (GBPDN), Institut Fédératif de Recherche Multidisciplinaire sur les Peptides n(o) 23 (IFRMP), UFR Médecine-Pharmacie de Rouen, France.
Biochimie. 1998 Oct;80(10):807-11. doi: 10.1016/s0300-9084(00)88875-6.
Glutamine is able to regulate the expression of various genes in rat hepatocytes. This includes genes coding for proteins involved in glutamine utilization, such as argininosuccinate synthetase (ureagenesis) or phosphoenolpyruvate carboxykinase (gluconeogenesis). Moreover, glutamine is also able to stimulate the expression of genes involved in the acute-phase response, such as the alpha 2-macroglobulin gene. The effect of glutamine on the regulation of gene expression may be explained, at least in part, by the cell swelling due to its sodium-dependent transport. The physiological significance of the effect of glutamine is discussed.
谷氨酰胺能够调节大鼠肝细胞中各种基因的表达。这包括编码参与谷氨酰胺利用的蛋白质的基因，如精氨琥珀酸合成酶（尿素生成）或磷酸烯醇式丙酮酸羧激酶（糖异生）。此外，谷氨酰胺还能够刺激参与急性期反应的基因的表达，如α2-巨球蛋白基因。谷氨酰胺对基因表达调节的作用至少部分可以通过其钠依赖性转运导致的细胞肿胀来解释。文中讨论了谷氨酰胺作用的生理意义。
