Kanig K, Nitschki J, Peiler-Ischikawa K
Arzneimittelforschung. 1976;26(6):1209-12.
3-(1-Naphthyl)-2-tetrahydrofuryl-propionic acid-beta-diethylester-hydrogenoxalate (naftidrofuryl) increased after a 15-day treatment with orally 200 mg/kg per day the 32P-incorporation rate of two nucleic acid fractions and of ATP, ADP and AMP of rat brains. In contrast to the findings of other authors no increased ATP content was observed. The increased incorporation of the alpha-phosphate during the de novo synthesis of AMP.
3-(1-萘基)-2-四氢呋喃基-丙酸-β-二乙酯-氢草酸酯(萘呋胺酯),经每日口服200mg/kg连续治疗15天后,可提高大鼠脑内两种核酸组分以及ATP、ADP和AMP的32P掺入率。与其他作者的研究结果相反,未观察到ATP含量增加。在AMP从头合成过程中α-磷酸的掺入增加。