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[萘呋胺酯对大鼠脑内核酸及腺苷磷酸中32P掺入的影响]

[The influence of naftidrofuryl on 32Pi-incorporation into nucleic acids and adenosine phosphates of the rat brain].

作者信息

Kanig K, Nitschki J, Peiler-Ischikawa K

出版信息

Arzneimittelforschung. 1976;26(6):1209-12.

PMID:989418
Abstract

3-(1-Naphthyl)-2-tetrahydrofuryl-propionic acid-beta-diethylester-hydrogenoxalate (naftidrofuryl) increased after a 15-day treatment with orally 200 mg/kg per day the 32P-incorporation rate of two nucleic acid fractions and of ATP, ADP and AMP of rat brains. In contrast to the findings of other authors no increased ATP content was observed. The increased incorporation of the alpha-phosphate during the de novo synthesis of AMP.

摘要

3-(1-萘基)-2-四氢呋喃基-丙酸-β-二乙酯-氢草酸酯(萘呋胺酯),经每日口服200mg/kg连续治疗15天后,可提高大鼠脑内两种核酸组分以及ATP、ADP和AMP的32P掺入率。与其他作者的研究结果相反,未观察到ATP含量增加。在AMP从头合成过程中α-磷酸的掺入增加。

相似文献

1
[The influence of naftidrofuryl on 32Pi-incorporation into nucleic acids and adenosine phosphates of the rat brain].[萘呋胺酯对大鼠脑内核酸及腺苷磷酸中32P掺入的影响]
Arzneimittelforschung. 1976;26(6):1209-12.
2
[The 32P-incorporation into nucleic acids and adenosine phosphates of the rat brain after acute and chronic influence of meclofenoxate (author's transl)].甲氯芬酯急性和慢性作用后大鼠脑内核酸及腺苷磷酸的³²P掺入(作者译)
Arzneimittelforschung. 1976;26(12):2155-8.
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[32P-incorporation in adenosine phosphates of the rat brain after oral application of vincamine for 2 weeks (author's transl)].
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Effects of naftidrofuryl on local cerebral glucose utilization in the rat.萘呋胺酯对大鼠局部脑葡萄糖利用的影响。
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Arch Int Pharmacodyn Ther. 1982 Dec;260(2):218-29.
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[Effect of naftidrofuryl on creatinine serum concentration and on PAH/inulin clearance in peripheral arterial occlusive diseases].
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In vitro effect of naftidrofuryl oxalate on cerebral mitochondria impaired by microsphere-induced embolism in rats.
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Therapie. 1975 Sep-Oct;30(5):777-88.