[The 32P-incorporation into nucleic acids and adenosine phosphates of the rat brain after acute and chronic influence of meclofenoxate (author's transl)].

Beta-Dimethylaminoethyl-p-chlorophenoxyacetate hydrochloride (meclofenoxate, Helfergin) was adminstered orally in dosages of 300 mg/kg 3 times during an 18-h period. The incorporation rate of the total and cytoplasmic RNA as well as of ATP, ADP and AMP decreased. Contradictory results were obtained after a 16-day treatment with orally 300 mg/kg per day: while the 32P-incorporation rate of the cytoplasmic RNA and the 3 adenosine phosphates increased, the nuclear RNA showed a correspondent diminishing. No changes of the ATP content could be observed in any group. The differences between the acute and chronic experiments could be explained by a different excitation of the animals and by the very different dosages. The increased 32P-incorporation into the cytoplasmic and into the adenosine phosphates in the chronic experiments are explained by a stimulation of the pentose phosphate shunt which yields mainly the phosphate group for the synthesis of AMP.