Gutsche H, Blumenbach L, Losert W, Wiemann H
Arzneimittelforschung. 1976;26(6):1227-9.
The time course of 1-butylbiguanide concentration in plasma and the urinary and fecal elimination of the substance were measured in six female elimination of the substance were measured in six female diabetic patients after oral administration of 100 mg of 14C-1-butylibiguanide hydrochloride as Sindiatil. The mean maximum plasma concentration was 37 mug/100 ml and was reached after about 2 1/2 h. At least semi-maximum plasma concentrations (greater than or equal 18 mug/100 ml) were maintained between the 1st and 8th h after administration. Within 24 h 64% of the administered dose were eliminated (36% via the kidneys, 28% with the faeces). After 3 days a total of 80% had been eliminated, one-half each in urine and faeces, respectively. The average time taken for 50% of maximum renal elimination, and thus of the absorbed quantity, to be excreted was 7.2 h.
对6名女性糖尿病患者口服100毫克作为Sindiatil的盐酸14C - 1 - 丁基双胍后，测定了血浆中1 - 丁基双胍浓度的时程以及该物质的尿排泄和粪排泄情况。平均最大血浆浓度为37微克/100毫升，约在2.5小时后达到。给药后第1小时至第8小时之间维持至少半最大血浆浓度（大于或等于18微克/100毫升）。在24小时内，64%的给药剂量被消除（36%经肾脏，28%随粪便）。3天后，总共80%被消除，尿液和粪便中各占一半。最大肾脏消除量的50%，即吸收量的50%被排泄的平均时间为7.2小时。
