Romundstad P, Haldorsen T, Rønneberg A
University Hospital of Trondheim, Department of Occupational Medicine, Norway.
Am J Ind Med. 1999 Feb;35(2):164-74. doi: 10.1002/(sici)1097-0274(199902)35:2<164::aid-ajim8>3.0.co;2-w.
In this study, we describe the methodology used for historical estimation of exposure to fluoride and to PAH in vertical stud Søderberg (VSS) potrooms at two Norwegian aluminum smelters. The assessment was performed in order to develop exposure data for epidemiological studies of cause-specific mortality and cancer incidence.
The estimation was performed in several steps. In the first step, we estimated the area concentrations of fluoride and PAH in periods with no measurements. Relationships between measured area concentrations and process parameters were investigated by statistical modeling. Process parameters and the models were then used to estimate area concentrations in periods lacking area measurement data. In the second step, the relationships between the area measurements and job specific exposure (personal measurements) were investigated by use of a measurement model. In the last step, the obtained relationships were used to estimate job specific exposure in different periods.
The range for the annual exposure estimates in the VSS-potrooms was 0.05-1.7 mg/m3 for fluoride and 3-3,437 micrograms/m3 for PAH.
Despite limitations of available measurements in the early production period, we have concluded that the exposure estimates from this study provide a reasonable tool for the estimation of dose-response relations in subsequent epidemiological analyses.
在本研究中，我们描述了挪威两家铝冶炼厂垂直立柱索德伯格（VSS）电解车间氟化物和多环芳烃暴露历史估计所使用的方法。进行该评估是为了获取用于特定病因死亡率和癌症发病率流行病学研究的暴露数据。
估计分几步进行。第一步，我们在没有测量数据的时期估计氟化物和多环芳烃的区域浓度。通过统计建模研究测量的区域浓度与工艺参数之间的关系。然后使用工艺参数和模型来估计缺乏区域测量数据时期的区域浓度。第二步，通过使用测量模型研究区域测量与特定工作暴露（个人测量）之间的关系。在最后一步中，利用获得的关系来估计不同时期的特定工作暴露。
VSS电解车间年度暴露估计范围为氟化物0.05 - 1.7毫克/立方米，多环芳烃3 - 3437微克/立方米。
尽管早期生产阶段可用测量存在局限性，但我们得出结论，本研究的暴露估计为后续流行病学分析中剂量反应关系的估计提供了合理工具。
