Romundstad P, Haldorsen T, Andersen A
The Cancer Registry of Norway, N-0310 Montebello, Oslo, Norway.
Occup Environ Med. 2000 Jul;57(7):495-9. doi: 10.1136/oem.57.7.495.
To investigate the relation between exposure to polycyclic aromatic hydrocarbons (PAHs) and the incidence of lung and bladder cancer among aluminium production workers.
The cohort comprised 1790 men employed for more than 5 years at a Norwegian aluminium plant contributing 36 587 person-years to the study. Historical exposure to PAHs was estimated by the use of industrial hygiene measurements and by a panel of three people familiar with the industry. Cancer incidence was investigated from 1953 to 1995. The observed cases of cancer among men were compared with expected numbers calculated from national rates for men, and dose-response relations were investigated by internal comparison by Poisson regression with age, period, smoking, and cumulative exposure included in the models. The effect of lagging exposure by 10, 20, and 30 years was also investigated.
The present study showed no increased risk of urinary bladder cancer or lung cancer with increasing cumulative exposure to PAHs. No significant changes in risk were found for different lag times.
Due to the small size of this study, a minor increase in risk could not be excluded.
研究铝生产工人接触多环芳烃（PAHs）与肺癌和膀胱癌发病率之间的关系。
该队列包括1790名在挪威一家铝厂工作超过5年的男性，为该研究贡献了36587人年。通过工业卫生测量以及由三名熟悉该行业的人员组成的小组来估计PAHs的历史暴露情况。对1953年至1995年期间的癌症发病率进行了调查。将男性中观察到的癌症病例与根据全国男性发病率计算出的预期数量进行比较，并通过在模型中纳入年龄、时期、吸烟和累积暴露情况的泊松回归进行内部比较来研究剂量反应关系。还研究了将暴露滞后10年、20年和30年的影响。
本研究表明，随着PAHs累积暴露量的增加，膀胱癌或肺癌风险没有增加。在不同的滞后时间未发现风险有显著变化。
由于本研究规模较小，不能排除风险有轻微增加的可能性。
