Akpek E K, Ertoy D, Kalayci D, Hasiripi H
Cornea and External Disease Service, The Wilmer Eye Institute, Johns Hopkins Hospital, Baltimore, Maryland 21287-9238, USA.
Cornea. 1999 Jan;18(1):59-62.
To report the efficacy of topical mitomycin C in preventing local recurrences after incomplete surgical excision of conjunctival squamous cell neoplasia.
Four patients presented with unilateral conjunctival tumors. Excisional biopsy results revealed conjunctival intraepithelial neoplasia with an intact basement membrane. Neoplastic cells were present in at least one of the surgical borders of the excised conjunctiva in all four cases. Patients were treated with topical mitomycin C 0.02% three times daily for 2 weeks to prevent recurrences.
All four patients were free of clinically detectable tumors after a mean follow-up period of 20 months (range, 16-23 months). Side effects included mild discomfort, redness, photophobia, and punctate epithelial keratopathy that subsided on discontinuation of the medication.
Postoperative topical mitomycin C application may be a useful adjunct to prevent recurrences in patients with incompletely excised conjunctival squamous cell neoplasia.
报告局部应用丝裂霉素C预防结膜鳞状细胞肿瘤不完全手术切除后局部复发的疗效。
4例患者出现单侧结膜肿瘤。切除活检结果显示结膜上皮内瘤变，基底膜完整。所有4例患者切除结膜的至少一个手术切缘均有肿瘤细胞。患者局部应用0.02%丝裂霉素C，每日3次，共2周，以预防复发。
平均随访20个月（范围16 - 23个月）后，所有4例患者均无临床可检测到的肿瘤。副作用包括轻度不适、眼红、畏光和点状上皮性角膜病变，停药后症状消退。
术后局部应用丝裂霉素C可能是预防结膜鳞状细胞肿瘤不完全切除患者复发的有用辅助方法。
