联合切除、冷冻疗法和术中丝裂霉素 C（EXCRIM）治疗结膜局部上皮内和鳞状细胞癌。
Combined excision, cryotherapy, and intraoperative mitomycin C (EXCRIM) for localized intraepithelial and squamous cell carcinoma of the conjunctiva.
机构信息
Ophthalmology Department, Istanbul University Cerrahpasa Medical School, Abacımahmut Sokak No:7-9 Daire:6, 34093, Istanbul, Aksaray, Turkey,
出版信息
Graefes Arch Clin Exp Ophthalmol. 2013 Sep;251(9):2201-4. doi: 10.1007/s00417-013-2437-x. Epub 2013 Aug 16.
BACKGROUND
To report the results of patients undergoing combined excision, cryotherapy, and intraoperative mitomycin-C (EXCRIM) for primary ocular surface squamous neoplasia (OSSN) METHODS: A retrospective review of a non-comparative interventional case series. Histopathologically confirmed primary localized (less than four clock hours) OSSN treated with EXCRIM using adjuvant 0.02 % mitomycin-C (MMC) were included in the study. The main outcome measures were recurrence and complications related to MMC.
RESULTS
The study enrolled 28 eyes of 28 patients with OSSN with a median age of 64.5 (range 43 to 84) years. The mean tumor size was 6.9 × 4.35 mm. There was corneal involvement in 23 of 28 (82 %). Seven patients (21 %) had delayed epithelial healing. Two of eight patients (25 %) with squamous cell carcinoma (SCC) had positive lateral margins. There were no recurrences over a mean follow-up of 49 months (range 24 to 96).
CONCLUSION
The excision of OSSN combined with cryotherapy and intraoperative MMC is effective with a low recurrence rate. Long-term follow-up yielded favorable results.
背景
报告接受联合切除术、冷冻疗法和术中丝裂霉素 C（EXCRIM）治疗原发性眼表面鳞状上皮肿瘤（OSSN）的患者的结果。
方法
回顾性非比较干预性病例系列研究。本研究纳入了接受 EXCRIM 联合辅助 0.02%丝裂霉素 C（MMC）治疗的经组织病理学证实的原发性局限性（小于四个时钟小时）OSSN 患者（n=28）。主要观察指标为与 MMC 相关的复发和并发症。
结果
本研究纳入了 28 例 OSSN 患者的 28 只眼，患者中位年龄为 64.5 岁（范围为 43 至 84 岁）。肿瘤平均大小为 6.9×4.35mm。28 只眼中有 23 只（82%）累及角膜。7 例（21%）患者出现延迟上皮愈合。8 例鳞状细胞癌（SCC）患者中有 2 例（25%）存在侧缘阳性。平均随访 49 个月（范围为 24 至 96 个月）后无复发。
结论
联合切除、冷冻疗法和术中 MMC 治疗 OSSN 有效，复发率低。长期随访结果良好。
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