Jarrett E E, Hall E
Immunology. 1984 Oct;53(2):365-73.
Previous studies recognized a prolonged suppression of egg-albumin (EA)-specific IgE responsiveness in the progeny of immunized female rats, and showed that an identical effect was produced by the administration of small amounts of specific IgG during the first few days of life. Both manipulations also elevated the primary IgG response to a subsequent immunization but with less consistency. We have now investigated the effects on the progeny of varying the type of maternal response by immunizing with antigen given with or without adjuvant. Mothers immunized with EA without adjuvant (by mouth or parenterally) in whom both IgE and IgG responses are thereby suppressed do not influence the antibody-responsiveness of their progeny. By contrast, mothers immunized with EA in adjuvant, a procedure which suppresses IgE but enhances IgG responsiveness to the antigen, transfer both effects to their offspring. In this way, both IgE-suppression and IgG-enhancement are seen to correlate with the transmission of maternal IgG. EA administered either by mouth or parenterally in the period up to 6 weeks after birth, suppresses both IgE and IgG responses to subsequent specific challenges in a dose-dependent manner. The results of feeding antigen to the progeny of (IgG-transmitting) immune mothers indicated that passive and active immunity in the young rat, although both suppressing IgE-responsiveness, do not have additive depressive effects.
先前的研究发现，免疫雌性大鼠的后代中，卵清蛋白（EA）特异性IgE反应性受到长期抑制，并且表明在出生后的头几天给予少量特异性IgG也会产生相同的效果。这两种操作还增强了对后续免疫的初次IgG反应，但一致性较差。我们现在通过用含或不含佐剂的抗原进行免疫来研究改变母体反应类型对后代的影响。用无佐剂的EA免疫（经口或肠胃外途径）的母亲，其IgE和IgG反应均受到抑制，不会影响其后代的抗体反应性。相比之下，用含佐剂的EA免疫的母亲，这种方法会抑制IgE但增强对该抗原的IgG反应性，并将这两种效应传递给后代。通过这种方式，可以看出IgE抑制和IgG增强均与母体IgG的传递相关。在出生后6周内的任何时间经口或肠胃外给予EA，均以剂量依赖的方式抑制对后续特异性刺激的IgE和IgG反应。给（传递IgG的）免疫母亲的后代喂食抗原的结果表明，幼鼠中的被动免疫和主动免疫虽然都抑制IgE反应性，但没有累加的抑制作用。
