Evensen A, Johansen J G, Udnaes I, Arnesen K
Acta Ophthalmol (Copenh). 1976 Dec;54(6):767-73. doi: 10.1111/j.1755-3768.1976.tb01796.x.
Metrizamide is a non-ionic water-soluble contrast medium which is isotonic with human blood and tissue fluid at a concentration of 170 mgI/ml. Retrobulbar injection of 3 ml isotonic metrizamide in the muscular conus of rabbits causes slight and inconstant cellulitis, but a similar reaction can also be found after injection of the same amount of saline. It seems probable that the introduction of fluid sufficient to cause an increase in the retrobulbar pressure can cause inflammatory changes in the orbital tissue, and that this is not always caused by the contrast medium itself. Four patients were examined by orbitography with injection of 4 ml isotonic metrizamide. There were no side effects, and the orbitograms showed contrast of good quality. Metrizamide is therefore considered very suitable for orbitography, especially in hospitals where computer-tomography is not yet available.
甲泛葡胺是一种非离子型水溶性造影剂，在浓度为170mgI/ml时与人体血液和组织液等渗。在兔肌圆锥内球后注射3ml等渗甲泛葡胺会引起轻微且不恒定的蜂窝织炎，但注射相同量的生理盐水后也会出现类似反应。似乎足以导致球后压力升高的液体注入可引起眼眶组织的炎症变化，而且这并不总是由造影剂本身引起的。对4例患者进行了眼眶造影，注射了4ml等渗甲泛葡胺。未出现副作用，眼眶造影片显示造影质量良好。因此，甲泛葡胺被认为非常适合用于眼眶造影，尤其是在尚未配备计算机断层扫描的医院。
