Suzuki S, Ito K, Iwabuchi T
J Neurosurg. 1977 Jul;47(1):79-85. doi: 10.3171/jns.1977.47.1.0079.
A non-ionic water-soluble contrast medium, Amipaque (metrizamide), was studied for use in ventriculography both experimentally and clinically, and identified as having markedly low toxicity. Twenty adult mongrel dogs were injected intraventricularly of intracisternally with 2.0 to 5.0 ml of Amipaque. It was found that Amipaque is safe compared with other water-soluble contrast media, especially relative to epileptogenic effect. The authors also carried out 17 clinical trials of ventriculography using 4.0 to 15.0 ml of Amipaque in 13 neurosurgical patients. There were no troublesome symptoms except for a mild headache as a side-effect in one patient, and Amipaque proved to be a satisfactory diagnostic contrast medium.
一种非离子型水溶性造影剂阿米培克（甲泛葡胺），在脑室造影方面进行了实验和临床研究，并被确定毒性极低。给20只成年杂种狗脑室内或脑池内注射2.0至5.0毫升阿米培克。结果发现，与其他水溶性造影剂相比，阿米培克是安全的，尤其是在致癫痫作用方面。作者还对13例神经外科患者进行了17次脑室造影临床试验，使用4.0至15.0毫升阿米培克。除1例患者出现轻微头痛这一副作用外，未出现其他不良反应，阿米培克被证明是一种令人满意的诊断造影剂。
