Magno M, Szidon J P
Am J Physiol. 1976 Dec;231(6):1777-82. doi: 10.1152/ajplegacy.1976.231.6.1777.
The effect of lymphatic ligation on relative lung water (g H2O/g dry lung) was studied in dogs. Raising left atrial pressure to 20 mmHg for 2 h in chronically lymphatic-ligated dogs (4 days) caused a significantly greater increase in relative lung water than the same hemodynamic challenge did in sham-operated and acutely lymphatic-ligated dogs. There was no significant difference in relative lung water between the acutely lymphatic-ligated and sham-operated dogs. At normal left atrial pressures, there was no significant difference in relative lung water between the sham-operated and chronically lymphatic-ligated dogs. Since the combined effects of chronic lymphatic ligation and left atrial hypertension is greater than the sum of the individual effects, it appears that chronic lymphatic ligation increases the susceptibility of the lung to hemodynamic edema, we suggest that chronic lymphatic ligation may have produced increases in the interstitial volume and protein mass that are undetectable by our technique. These increases, in turn, could lead to a reduction in tissue safety factors against hemodynamic pulmonary edema.
在犬类中研究了淋巴管结扎对相对肺水含量（克水/克干肺）的影响。在慢性淋巴管结扎犬（4天）中将左心房压力升至20 mmHg并持续2小时，相较于假手术犬和急性淋巴管结扎犬接受相同血流动力学刺激时，相对肺水含量的增加显著更大。急性淋巴管结扎犬和假手术犬的相对肺水含量无显著差异。在正常左心房压力下，假手术犬和慢性淋巴管结扎犬的相对肺水含量无显著差异。由于慢性淋巴管结扎和左心房高压的联合作用大于各自作用之和，似乎慢性淋巴管结扎增加了肺对血流动力学性水肿的易感性，我们认为慢性淋巴管结扎可能导致了间质体积和蛋白量的增加，而我们的技术无法检测到这些增加。反过来，这些增加可能导致对抗血流动力学性肺水肿的组织安全系数降低。
