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[血清素的D-、M-和T-拮抗剂对人血小板吸收血清素的影响]

[Effect of D-, M- and T-antagonists of serotonin on its absorption by human thrombocytes].

作者信息

Oksenkryg G F

出版信息

Biull Eksp Biol Med. 1976 Sep;82(9):1076-7.

PMID:990460
Abstract

Serotonin M-antagonist -- cocaine, and D-antagonist -- dihydroergotamine depressed the serotonin absorption by guman platelets considerably (in a concentration of 10(-4) by 90 and 62%, respectively). Serotonin M-antagonist--morphine, D-antagonist--deseryl, and T-antagonist--typindol inhibited serotonin absorption much less (in a concentration of 10(-4)M by 33, 28 and 18%, respectively). It is supposed that "serotonin" centre of the membrane carrier participating in the process of transmembrane serotonin transport was not identical to any definite type of serotonin receptor.

摘要

5-羟色胺M拮抗剂——可卡因和D拮抗剂——二氢麦角胺可显著抑制人血小板对5-羟色胺的吸收(浓度为10⁻⁴时,分别抑制90%和62%)。5-羟色胺M拮抗剂——吗啡、D拮抗剂——地昔帕明和T拮抗剂——替吲哚对5-羟色胺吸收的抑制作用则小得多(浓度为10⁻⁴M时,分别抑制33%、28%和18%)。据推测,参与5-羟色胺跨膜转运过程的膜载体“5-羟色胺”中心与任何特定类型的5-羟色胺受体都不相同。

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