van Thiel D H, Lester R
Alcohol Clin Exp Res. 1978 Jul;2(3):265-70. doi: 10.1111/j.1530-0277.1978.tb05810.x.
Reduced plasma levels of testosterone and a high frequency of azoospermia have frequently been reported in alcoholic men. Despite the high grade of gonadal failure present, plasma gonadotropins have ranged from normal to only moderately increased. This has been interpreted as suggesting that a central hypothalamic-pituitary defect also might exist in these men. Clomiphene stimulation studies have been consistent with the hypothesis of a central defect. The present work consists of studies utilizing luteinizing hormone-releasing factor and thyrotropin-releasing factor in an effort to examine the hypothesis of whether this central defect exists and, if so, whether at an anatomic, hypothalamic, or pituitary level.
经常有报道称，酗酒男性的血浆睾酮水平降低且无精子症发生率很高。尽管存在严重的性腺功能衰竭，但血浆促性腺激素水平从正常到仅中度升高不等。这被解释为表明这些男性可能也存在中枢下丘脑 - 垂体缺陷。克罗米芬刺激研究与中枢缺陷的假设一致。目前的工作包括利用促黄体生成素释放因子和促甲状腺激素释放因子进行研究，以检验是否存在这种中枢缺陷的假设，如果存在，是在解剖学、下丘脑还是垂体水平上。
