慢性酒精中毒男性的女性化：一种表述。
Feminization of chronic alcoholic men: a formulation.
作者信息
Van Thiel D H
出版信息
Yale J Biol Med. 1979 Mar-Apr;52(2):219-25.
Abstract
A review of the factors historically thought to contribute to the feminization of men with Laennec's cirrhosis is presented. Objective scientific data is presented both in support of and in rejection of such factors when available. Recent hypotheses about the significance of an altered estrogen to androgen (E/T) ratio as being important in the pathogenesis of feminization also are discussed. Finally, a hypothesis which incorporates the findings of hypogonadism and cirrhosis with portal-systemic shunting is presented as a pathogenic mechanism for the feminization of men with alcohol-induced Laennec's cirrhosis.
摘要
本文综述了历史上被认为与Laennec肝硬化男性女性化有关的因素。如有客观科学数据，将同时列出支持和反驳这些因素的数据。还讨论了关于雌激素与雄激素（E/T）比值改变在女性化发病机制中具有重要意义的最新假说。最后，提出了一种将性腺功能减退和肝硬化与门体分流的研究结果相结合的假说，作为酒精性Laennec肝硬化男性女性化的发病机制。
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Feminization of chronic alcoholic men: a formulation.慢性酒精中毒男性的女性化：一种表述。
Yale J Biol Med. 1979 Mar-Apr;52(2):219-25.
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本文引用的文献
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Endocrine changes associated with Laennec's cirrhosis of the liver.与Laennec肝硬化相关的内分泌变化。
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The testis, breast and prostate of men who die of cirrhosis of the liver.死于肝硬化的男性的睾丸、乳房和前列腺。
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Serum prolactin levels in patients with gynecomastia.男性乳房发育症患者的血清催乳素水平。
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Conversion of androstenedione to estrone by human tissue.人体组织将雄烯二酮转化为雌酮的过程。
J Clin Endocrinol Metab. 1972 Oct;35(4):627-30. doi: 10.1210/jcem-35-4-627.
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Aromatization of androstenedione by the diencephalon.间脑对雄烯二酮的芳香化作用。
J Clin Endocrinol Metab. 1971 Aug;33(2):368-70. doi: 10.1210/jcem-33-2-368.
8
Plasma testosterone, estradiol, and gonadotrophins in hepatic insufficiency.肝功能不全时的血浆睾酮、雌二醇和促性腺激素
Gastroenterology. 1973 Jan;64(1):111-5.
9
Estrogen-androgen imbalance in hepatic cirrhosis. Studies in 13 male patients.肝硬化中的雌激素 - 雄激素失衡。对13名男性患者的研究。
Ann Intern Med. 1973 Aug;79(2):198-203. doi: 10.7326/0003-4819-79-2-198.
10
Androgen metabolism in cirrhosis of the liver.肝脏肝硬化中的雄激素代谢。
Metabolism. 1973 May;22(5):695-701. doi: 10.1016/0026-0495(73)90241-2.
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