Van Thiel D H, Lester R, Vaitukaitis J
J Clin Endocrinol Metab. 1978 Sep;47(3):499-507. doi: 10.1210/jcem-47-3-499.
To characterize the defect in the hypothalamic-pituitary-gonadal axis of alcoholic men, acute and chronic LRF responses were evaluated in 22 chronic alcoholic men with varying degrees of biochemically and histologically confirmed liver disease. In addition, acute LRF responses in 14 normal men, before and at the end of 72 h of administration of 2 ml/kg/day 95% ethanol, were evaluated. The alcoholics hd significantly reduced basal testosterone and elevated gonadotropin levels (both FSH and LH) compared to the normal volunteers (P less than 0.02). Serum concentrations of estradiol and PRL did not differ between alcoholics and normal volunteers. A 100-micrograms bolus of LRF resulted in a 3-fold increase of LH in alcoholic men as compared to a 6-fold increase of serum LH in normal volunteers. No significant difference in the LRF-induced FSH responses was observed. When the response of normal volunteers to LRF before and after ethanol administration was evaluated, basal levels of both gonadotropins were increased after alcohol administration and a reduced LRF-induced LH response was observed. Based upon these results, we conclude that: 1) the central hypothalamic-pituitary defect known to exist for LH secretion is in part due to inadequate pituitary secretion and 2) acute alcohol ingestion in normal men suppresses the LRF-induced LH but not the FSH response.
为了描述酒精性肝病男性下丘脑 - 垂体 - 性腺轴的缺陷，我们评估了22名患有不同程度生化和组织学确诊肝病的慢性酒精性肝病男性的急性和慢性促性腺激素释放因子（LRF）反应。此外，还评估了14名正常男性在每天按2 ml/kg剂量给予95%乙醇72小时之前和结束时的急性LRF反应。与正常志愿者相比，酒精性肝病患者的基础睾酮水平显著降低，促性腺激素水平（卵泡刺激素FSH和黄体生成素LH）升高（P < 0.02）。酒精性肝病患者与正常志愿者之间的雌二醇和催乳素血清浓度没有差异。静脉注射100微克LRF后，酒精性肝病男性的LH增加了3倍，而正常志愿者的血清LH增加了6倍。未观察到LRF诱导的FSH反应有显著差异。当评估正常志愿者在乙醇给药前后对LRF的反应时，发现给药后两种促性腺激素的基础水平均升高，并且观察到LRF诱导的LH反应降低。基于这些结果，我们得出以下结论：1）已知存在的LH分泌中枢下丘脑 - 垂体缺陷部分是由于垂体分泌不足；2）正常男性急性摄入酒精会抑制LRF诱导的LH反应，但不抑制FSH反应。
