Tyrrell C J, Peckham M J
Br J Urol. 1976 Oct;48(5):363-70. doi: 10.1111/j.1464-410x.1976.tb06654.x.
The response to radiation therapy of lymph nodes metastases from testicular teratomas has been examined in 117 Stage I and II patients treated between 1962 and 1972. It is not possible to obtain reliable estimates of the percentage Stage I patients with occult retroperitoneal node metastases; however, available evidence suggests that spread of tumour to the lymph nodes has occurred in a proportion (possibly as many as 50%) of patients in this category. Radiation therapy is an effective method of achieving tumour eradication and overall survival results in this group are good (84%). In a smaller group of Stage II patients with unequivocal lymphographic evidence of nodal spread, the effectiveness of irradiation is dependent upon tumour volume. In those patients with metastases 2 centimetres or less in diameter, the results of treatment are similar to Stage I and we have designated this group Stage IIa. In those patients with larger volume metastases, two thirds have developed abdominal node relapse, in most cases associated with distant spread. We have designated this group Stage IIb. The implications of these observations for overall management are discussed.
对1962年至1972年间接受治疗的117例Ⅰ期和Ⅱ期睾丸畸胎瘤淋巴结转移患者的放射治疗反应进行了研究。对于Ⅰ期患者中隐匿性腹膜后淋巴结转移的百分比，无法获得可靠的估计；然而，现有证据表明，该类患者中有一定比例（可能多达50%）发生了肿瘤向淋巴结的转移。放射治疗是实现肿瘤根除的有效方法，该组患者的总体生存结果良好（84%）。在一小部分有明确淋巴造影证据显示有淋巴结转移的Ⅱ期患者中，放射治疗的有效性取决于肿瘤体积。在那些转移灶直径2厘米或更小的患者中，治疗结果与Ⅰ期相似，我们将该组定为Ⅱa期。在那些转移灶体积较大的患者中，三分之二出现了腹部淋巴结复发，大多数情况下伴有远处转移。我们将该组定为Ⅱb期。讨论了这些观察结果对整体治疗的意义。
