甲基黄嘌呤对小鼠脑组织中前体掺入蛋白质和RNA的影响。
The influence of methylxanthines on precursor incorporation into protein and RNA of mouse brain.
作者信息
Boksay I, Csanyi V, Gervai J, Lajtha A
出版信息
Brain Res. 1976 Nov 26;117(2):297-304. doi: 10.1016/0006-8993(76)90737-x.
PMID:990917
Abstract
Pentoxifyline at 1 mM had no effect on [14C]isoleucine incorporation into mouse brain tissue suspension. At 5-20 mM, this compound inhibited incorporation. The inhibition was prompt, and it was reversible. Aminophyline at 3-12 mM produced inhibition, but theophyline at 2-16 mM had no effect. Pentoxifylline inhibited the incorporation of uridine into brain RNA to the same extent and with a similar time course as its effect on protein synthesis.
摘要
1毫摩尔的己酮可可碱对[14C]异亮氨酸掺入小鼠脑组织悬液没有影响。在5 - 20毫摩尔时，该化合物抑制掺入。抑制作用迅速且可逆。3 - 12毫摩尔的氨茶碱产生抑制作用，但2 - 16毫摩尔的茶碱没有影响。己酮可可碱抑制尿苷掺入脑RNA的程度和时间进程与其对蛋白质合成的影响相同。
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