Calne R Y
Ann Surg. 1978 Aug;188(2):129-38. doi: 10.1097/00000658-197808000-00001.
Liver transplantation has had a long gestation period in being accepted as standard therapy. The main reason for this is the formidable operation to which the patient is subjected and because of this, referral of cases tends to be too late. Increasing confidence in the operation should result in earlier surgery. The low incidence of uncontrollable rejection is an encouraging finding which should, in the future, make the results of grafting for nonmalignant parenchymatous liver disease better than those currently obtained with kidney grafts from cadaver donors. The surgery requires a large team of strongly motivated doctors, nurses and technicians, who must have continuing experience with technically successful orthotopic liver grafts in experimental animals.
肝移植被接受为标准治疗方法经历了漫长的孕育期。主要原因是患者要接受的手术难度极大，正因如此，病例转诊往往过晚。对该手术信心的增强应会促使更早进行手术。不可控排斥发生率较低是一个令人鼓舞的发现，未来这应会使非恶性实质性肝病的移植结果优于目前来自尸体供体的肾移植结果。该手术需要一大群积极性很高的医生、护士和技术人员，他们必须在实验动物的原位肝移植技术成功方面有持续的经验。
