Hatano S, Keane D M, Boggs R E, El-Naggar M A, Sadove M S
Can Anaesth Soc J. 1976 Nov;23(6):648-56. doi: 10.1007/BF03006748.
Two hundred open-heart cases were anaesthetized with a diazepam-ketamine combination. The results were excellent. A "Micro-Mini" drip technique insured low, even, but adequate dose levels of ketamine and less drug was used. Induction and maintenance are simple and smooth. Effects on the cardiovascular system and respiratory system are minimal. The margin of safety is wide and 100% oxygen can be used whenever needed.