药物研发中的DNA微阵列技术。
DNA microarrays in drug discovery and development.
作者信息
Debouck C, Goodfellow P N
机构信息
SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19406, USA.
出版信息
Nat Genet. 1999 Jan;21(1 Suppl):48-50. doi: 10.1038/4475.
DOI:10.1038/4475
PMID:9915501
Abstract
DNA microarrays can be used to measure the expression patterns of thousands of genes in parallel, generating clues to gene function that can help to identify appropriate targets for therapeutic intervention. They can also be used to monitor changes in gene expression in response to drug treatments. Here, we discuss the different ways in which microarray analysis is likely to affect drug discovery.
摘要
DNA微阵列可用于同时测量数千个基因的表达模式，生成有关基因功能的线索，有助于确定合适的治疗干预靶点。它们还可用于监测基因表达随药物治疗的变化。在此，我们讨论微阵列分析可能影响药物发现的不同方式。
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