蛛网膜下腔出血后脑血管痉挛的病因：反对5-羟色胺在急性痉挛产生中起主要作用的证据。
Aetiology of cerebral arterial spasm following subarachnoid haemorrhage: evidence against a major involvement of 5-hydroxy-tryptamine in the production of acute spasm.
作者信息
Boullin D J, Du Boulay G H, Rogers A T
出版信息
Br J Clin Pharmacol. 1978 Sep;6(3):203-15. doi: 10.1111/j.1365-2125.1978.tb04586.x.
Abstract
Acute cerebral arterial spasm was produced in baboons by intracisternal injection of blood or 5-hydroxytryptamine (5-HT). Blood induced spasm was not antagonized by the potent 5-HT antagonist BW501C67, but 5-HT induced cerebral arterial spasm was largely antagonized. Blood platelets from baboons were isolated and aggregated with adenosine diphosphate (ADP) and 5-HT. 5-HT induced platelet aggregation was abolished by BW501C67 It was also abolished after intracisternal administration of the drug. Thus it is concluded that BW501C67 antagonized 5-HT induced cerebral arterial spasm. BW501C67 also failed to antagonize contractions produced by human cerebrospinal fluid, serum and platelet extracts on the isolated human basilar artery, the isolated rat fundus and aorta. These results suggest that the role of 5-HT in the aetiology of human cerebral spasm may be minimal.
摘要
通过向狒狒脑池内注射血液或5-羟色胺（5-HT）来诱发急性脑动脉痉挛。强效5-HT拮抗剂BW501C67不能拮抗血液诱导的痉挛，但能很大程度上拮抗5-HT诱导的脑动脉痉挛。分离狒狒的血小板，并用二磷酸腺苷（ADP）和5-HT使其聚集。BW501C67可消除5-HT诱导的血小板聚集。在脑池内给药后也可消除该现象。因此得出结论，BW501C67可拮抗5-HT诱导的脑动脉痉挛。BW501C67也不能拮抗人脑脊液、血清和血小板提取物对离体人基底动脉、离体大鼠胃底和主动脉产生的收缩作用。这些结果表明，5-HT在人类脑痉挛病因学中的作用可能微乎其微。
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本文引用的文献
1
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2
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J Appl Physiol. 1958 Nov;13(3):515-20. doi: 10.1152/jappl.1958.13.3.515.
3
A sensitive method for the assay of 5-hydroxytryptamine.一种测定5-羟色胺的灵敏方法。
Br J Pharmacol Chemother. 1957 Sep;12(3):344-9. doi: 10.1111/j.1476-5381.1957.tb00146.x.
4
Reactions of strips of rabbit aorta to epinephrine, isopropylarterenol, sodium nitrite and other drugs.兔主动脉条对肾上腺素、异丙肾上腺素、亚硝酸钠及其他药物的反应。
J Pharmacol Exp Ther. 1953 Jun;108(2):129-43.
5
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6
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7
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J Physiol. 1972 Mar;221(2):415-26. doi: 10.1113/jphysiol.1972.sp009758.
8
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9
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10
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J Neurosurg. 1974 Apr;40(4):451-8. doi: 10.3171/jns.1974.40.4.0451.
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