Fulker D W, Cherny S S, Sham P C, Hewitt J K
Institute for Behavioral Genetics, University of Colorado, Boulder, CO 80309-0447, USA.
Am J Hum Genet. 1999 Jan;64(1):259-67. doi: 10.1086/302193.
An extension to current maximum-likelihood variance-components procedures for mapping quantitative-trait loci in sib pairs that allows a simultaneous test of allelic association is proposed. The method involves modeling of the allelic means for a test of association, with simultaneous modeling of the sib-pair covariance structure for a test of linkage. By partitioning of the mean effect of a locus into between- and within-sibship components, the method controls for spurious associations due to population stratification and admixture. The power and efficacy of the method are illustrated through simulation of various models of both real and spurious association.
本文提出了一种对当前用于同胞对中数量性状位点定位的最大似然方差分量程序的扩展方法，该方法允许同时检验等位基因关联。该方法包括对等位基因均值进行建模以检验关联，同时对同胞对协方差结构进行建模以检验连锁。通过将一个位点的平均效应分解为同胞间和同胞内成分，该方法可控制由于群体分层和混合导致的虚假关联。通过对真实和虚假关联的各种模型进行模拟，说明了该方法的功效和效能。
