[Genotype analysis of biochemical status in people irradiated with significant doses of radiation].

416 workers of the enterprise of a nuclear industry aged from 52 to 78 years exposed to chronic influence of external gamma-irradiation in summary dozes 1.0-7.56 Gy and plutonium-239 incorporation, (in 32.3% of cases exceeding the allowable limit) were studied. A correlation between a complex of 26 biochemical and immunochemical parameters and the radiating factors was investigated at different haptoglobin genotypes (Hp). It was established, that the greatest number of changes of biochemical parameters related to radiating influence, was observed at the people with a genotype Hp 2-2 (7 parameters), to a lesser degree--at a genotype Hp 2-1 (5 parameters) and in some more smaller degree--at a genotype Hp 1-1 (4 parameters). All investigated people with a genotype 2-2 were characterised by increase of serum protein entropy.