Moseley Pope L
Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Internal Medicine, University of New Mexico, Albuquerque, New Mexico 87131-5271, USA.
Ann N Y Acad Sci. 1998 Sep 29;856:206-213. doi: 10.1111/j.1749-6632.1998.tb08327.x.
The heat shock proteins (HSPs) are important in the cellular response to stress and in cellular homeostatic functions such as protein synthesis and protein transport across membranes. An emerging body of data supports a role for HSPs in the inflammatory response, suggesting that HSPs participate in cytokine signal transduction and in the control of cytokine gene expression, that HSPs enhance antigen presentation to T lymphocytes, and that HSPs displayed on the surface of cells are important in targeting cytotoxic cells. Because changes in HSP accumulation occur in the whole organism under physiologic conditions, understanding the role of HSPs in the immune/inflammatory response may aid in understanding the organism's response to danger.
热休克蛋白（HSPs）在细胞对应激的反应以及细胞稳态功能（如蛋白质合成和跨膜蛋白质转运）中起着重要作用。越来越多的数据支持HSPs在炎症反应中的作用，这表明HSPs参与细胞因子信号转导和细胞因子基因表达的调控，HSPs增强抗原呈递给T淋巴细胞，并且细胞表面展示的HSPs在靶向细胞毒性细胞方面很重要。由于在生理条件下整个生物体中都会发生HSPs积累的变化，了解HSPs在免疫/炎症反应中的作用可能有助于理解生物体对危险的反应。
