Solano-Aguilar G I, Pijoan C, Rapp-Gabrielson V, Collins J, Carvalho L F, Winkelman N
Department of Clinical and Population Sciences, College of Veterinary Medicine, University of Minnesota, St Paul 55108, USA.
Am J Vet Res. 1999 Jan;60(1):81-7.
To evaluate the impact of maternal antibodies after challenge exposure of baby pigs with a homologous serovar of Haemophilus parasuis.
7 gilts and their litters from a high health status farm.
Gilts were vaccinated twice with a commercial bacterin that contained H parasuis serovar 4 and 5 or, as a control, adjuvant only. A group of pigs was also vaccinated similarly before challenge exposure. After early and late challenge exposure at 3 and 4 weeks, respectively, all pigs from vaccinated gilts were evaluated for clinical signs of infection, lesions, and antibody titer.
All pigs coming from control gilts had severe signs of H parasuis infection. Macroscopic lesions included polyserositis and pneumonia, and bacteriologic examination confirmed H parasuis as the etiologic agent. Vaccinated pigs born to vaccinated gilts did not have clinical signs of disease. However, some vaccinated pigs born to control gilts had signs of nervous system dysfunction and lameness. There was no difference in lesion scores between early or late challenge exposure, but lesions scores for pigs from vaccinated and control gilts were different (P < 0.01).
Under these experimental conditions, immune-naive and vaccinated pigs from vaccinated gilts were protected against systemic lesions when challenge exposed with a virulent strain of H parasuis.
Vaccination of the gilt and pigs protects the latter from polyserositis, but results are not different from those for nonvaccinated pigs from vaccinated gilts. Maternal antibodies did not seem to interfere with vaccination of pigs at 1 and 3 weeks of age.
评估用猪副猪嗜血杆菌同源血清型对仔猪进行激发暴露后母源抗体的影响。
来自一个高健康状态猪场的7头后备母猪及其仔猪。
给后备母猪用含有猪副猪嗜血杆菌血清型4和5的商业菌苗进行两次免疫接种，或作为对照，仅接种佐剂。一组猪在激发暴露前也进行类似的免疫接种。分别在3周和4周进行早期和晚期激发暴露后，对来自免疫接种后备母猪的所有仔猪进行感染临床症状、病变和抗体滴度评估。
来自对照后备母猪的所有仔猪均有猪副猪嗜血杆菌感染的严重症状。肉眼可见病变包括多浆膜炎和肺炎，细菌学检查证实猪副猪嗜血杆菌为病原体。免疫接种后备母猪所生的免疫接种仔猪没有疾病临床症状。然而，对照后备母猪所生的一些免疫接种仔猪有神经系统功能障碍和跛行症状。早期或晚期激发暴露之间的病变评分没有差异，但免疫接种和对照后备母猪所生仔猪的病变评分不同（P < 0.01）。
在这些实验条件下，当用猪副猪嗜血杆菌强毒株进行激发暴露时，来自免疫接种后备母猪的未免疫和已免疫仔猪可免受全身病变影响。
对后备母猪和仔猪进行免疫接种可保护仔猪免受多浆膜炎影响，但结果与来自免疫接种后备母猪的未免疫仔猪无异。母源抗体似乎不干扰1周龄和3周龄仔猪的免疫接种。
