受体阻断药物对苯丙胺所致脑糖原耗竭的影响。
Effect of receptor blocking drugs on the depletion of brain glycogen by amphetamine.
作者信息
Hutchins D A, Rogers K J
出版信息
Br J Pharmacol. 1971 Nov;43(3):504-13. doi: 10.1111/j.1476-5381.1971.tb07181.x.
Abstract
- Amphetamine sulphate (5 mg/kg), administered intraperitoneally, reduces the concentration of glycogen in the mouse brain by 25-30% after 30 minutes.2. The effect of several receptor blocking drugs on the amphetamine-induced cerebral glycogenolysis was studied.3. DL-Propranolol (0.25 mg/kg) and pronethalol (10 mg/kg) antagonized the depletion of brain glycogen by amphetamine.4. Phentolamine, methysergide, atropine and mepyramine failed to antagonize the amphetamine-induced glycogenolysis.5. D-Propranolol, chlorpromazine and phenoxybenzamine antagonized the glycogenolytic effect of amphetamine only when administered in sedative doses.6. It is concluded that amphetamine-induced glycogenolysis in the mouse brain may be mediated through a beta-adrenoceptor.
摘要
硫酸苯丙胺（5毫克/千克）腹腔注射后30分钟，可使小鼠脑内糖原浓度降低25 - 30%。
研究了几种受体阻断药物对苯丙胺诱导的脑糖原分解的影响。
DL-普萘洛尔（0.25毫克/千克）和丙萘洛尔（10毫克/千克）可拮抗苯丙胺引起的脑糖原消耗。
酚妥拉明、麦角酰二乙胺、阿托品和甲吡胺未能拮抗苯丙胺诱导的糖原分解。
D-普萘洛尔、氯丙嗪和酚苄明仅在镇静剂量下给药时，才拮抗苯丙胺的糖原分解作用。
得出的结论是，苯丙胺诱导的小鼠脑内糖原分解可能通过β-肾上腺素能受体介导。
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