• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Effect of receptor blocking drugs on the depletion of brain glycogen by amphetamine.受体阻断药物对苯丙胺所致脑糖原耗竭的影响。
Br J Pharmacol. 1971 Nov;43(3):504-13. doi: 10.1111/j.1476-5381.1971.tb07181.x.
2
[Effect of antiadrenergic and antidopaminergic drugs on methamphetamine induced changes in motor activity and cerebral glycogen content of mice].[抗肾上腺素能和抗多巴胺能药物对甲基苯丙胺所致小鼠运动活动及脑糖原含量变化的影响]
Arzneimittelforschung. 1974 Aug;24(8):1087-8.
3
The effects of beta adrenoceptor blocking agents on the membrane potential and spike generation in the smooth muscle of guinea-pig taenia coli.β肾上腺素能受体阻断剂对豚鼠结肠带平滑肌膜电位和动作电位产生的影响。
Br J Pharmacol. 1970 Jan;38(1):12-9. doi: 10.1111/j.1476-5381.1970.tb10332.x.
4
Role of dopamine in the anorexigenic effect of DITA; comparison with d-amphetamine.多巴胺在DITA的厌食作用中的角色；与右旋苯丙胺的比较。
Eur J Pharmacol. 1976 Nov;40(1):39-44. doi: 10.1016/0014-2999(76)90351-4.
5
Release of brain dopamine as the probable mechanism for the hypothermic effect of D-amphetamine.脑多巴胺的释放可能是右旋苯丙胺降温作用的机制。
Nature. 1972 Dec 22;240(5382):477-8. doi: 10.1038/240477a0.
6
Effect of antidepressant and adrenergic blocking drugs on hyperthermia induced by reserpine.抗抑郁药和肾上腺素能阻断药对利血平所致体温过高的影响。
Arch Int Pharmacodyn Ther. 1967 Feb;165(2):384-93.
7
Effects of adrenoceptor blocking agents on body temperature.肾上腺素能受体阻断剂对体温的影响。
Br J Pharmacol. 1971 Nov;43(3):543-54. doi: 10.1111/j.1476-5381.1971.tb07184.x.
8
The effect of certain drugs on amphetamine-induced stereotyped behavior and brain amphetamine levels in the rat.某些药物对大鼠中苯丙胺诱导的刻板行为及脑内苯丙胺水平的影响。
Biol Psychiatry. 1974 Aug;9(1):3-10.
9
Salivation in mice as an index of adrenergic activity. I. Salivation and temperature responses to d-amphetamine and other sialogogues and the effects of adrenergic blocking agents.小鼠唾液分泌作为肾上腺素能活性指标。I. 对d-苯丙胺和其他催涎剂的唾液分泌及温度反应以及肾上腺素能阻断剂的作用
Arch Int Pharmacodyn Ther. 1972 Oct;199(2):318-32.
10
Effect of depletion of cerebral monoamines on the concentration of glycogen and on amphetamine-induced glycogenolysis in the brain.脑内单胺耗竭对脑内糖原浓度及苯丙胺诱导的糖原分解的影响。
Br J Pharmacol. 1973 May;48(1):19-29. doi: 10.1111/j.1476-5381.1973.tb08218.x.

引用本文的文献

1
Increased lactate levels and reduced pH in postmortem brains of schizophrenics: medication confounds.精神分裂症患者死后大脑中乳酸水平升高和pH值降低：药物干扰因素
J Neurosci Methods. 2008 Mar 30;169(1):208-13. doi: 10.1016/j.jneumeth.2007.11.017. Epub 2007 Nov 29.
2
Effect of depletion of cerebral monoamines on the concentration of glycogen and on amphetamine-induced glycogenolysis in the brain.脑内单胺耗竭对脑内糖原浓度及苯丙胺诱导的糖原分解的影响。
Br J Pharmacol. 1973 May;48(1):19-29. doi: 10.1111/j.1476-5381.1973.tb08218.x.
3
The effect of pargyline and desmethylimipramine on monoamine concentrations and amphetamine-induced glycogenolysis in the mouse brain.帕吉林和去甲丙咪嗪对小鼠脑内单胺浓度及苯丙胺诱导的糖原分解的影响。
Br J Pharmacol. 1979 Mar;65(3):489-94. doi: 10.1111/j.1476-5381.1979.tb07856.x.
4
L-Dopa feeding suppression: effect on catecholamine neurons of the perifornical lateral hypothalamus.左旋多巴喂养抑制：对穹窿周外侧下丘脑儿茶酚胺能神经元的影响。
Psychopharmacology (Berl). 1979 Mar 28;61(3):273-80. doi: 10.1007/BF00432272.

本文引用的文献

1
The effects of anaesthetics and of convulsants on the lactic acid content of the brain.麻醉剂和惊厥剂对脑乳酸含量的影响。
Biochem J. 1938 Nov;32(11):1908-18. doi: 10.1042/bj0321908.
2
Adenyl cyclase. III. The effect of catecholamines and choline esters on the formation of adenosine 3',5'-phosphate by preparations from cardiac muscle and liver.腺苷酸环化酶。III. 儿茶酚胺和胆碱酯对心肌和肝脏制剂生成3',5'-磷酸腺苷的影响。
J Biol Chem. 1962 Apr;237:1233-8.
3
The effect of adrenergic blocking agents on some metabolic actions of catecholamines.肾上腺素能阻断剂对儿茶酚胺某些代谢作用的影响。
J Pharmacol Exp Ther. 1961 Oct;134:18-27.
4
EFFECT OF DRUGS ON THE UPTAKE, RELEASE, AND METABOLISM OF H3-NOREPINEPHRINE IN THE RAT BRAIN.药物对大鼠脑中H3-去甲肾上腺素摄取、释放及代谢的影响
J Pharmacol Exp Ther. 1965 Jul;149:43-9.
5
EFFECTS OF D-AMPHETAMINE UPON BRAIN AMINE CONTENT AND LOCOMOTOR ACTIVITY OF MICE.右旋苯丙胺对小鼠脑内胺含量及运动活性的影响。
J Pharmacol Exp Ther. 1965 Jan;147:96-102.
6
THE EFFECT OF FASTING ON THE HYPERGLYCAEMIC RESPONSES TO CATECHOL AMINES IN RATS.禁食对大鼠儿茶酚胺所致高血糖反应的影响
Br J Pharmacol Chemother. 1964 Apr;22(2):267-74. doi: 10.1111/j.1476-5381.1964.tb02032.x.
7
STRESS-INDUCED RELEASE OF BRAIN NOREPINEPHRINE AND ITS INHIBITION BY DRUGS.应激诱导的脑去甲肾上腺素释放及其药物抑制作用。
J Pharmacol Exp Ther. 1964 Jan;143:90-5.
8
NEUROHORMONE LEVELS IN BRAIN AFTER CNS STIMULATION INCLUDING ELECTROTHERAPY.中枢神经系统刺激（包括电疗法）后大脑中的神经激素水平。
J Neuropsychiatr. 1964 Feb;5:153-8.
9
EFFECT OF CHLORPROMAZINE OR HALOPERIDOL ON FORMATION OF 3METHOXYTYRAMINE AND NORMETANEPHRINE IN MOUSE BRAIN.氯丙嗪或氟哌啶醇对小鼠脑内3-甲氧基酪胺和去甲变肾上腺素形成的影响。
Acta Pharmacol Toxicol (Copenh). 1963;20:140-4. doi: 10.1111/j.1600-0773.1963.tb01730.x.
10
The pharmacological properties of chlorpromazine sulfoxide, a major metabolite of chlorpromazine; a comparison with chlorpromazine.氯丙嗪的主要代谢产物氯丙嗪亚砜的药理特性；与氯丙嗪的比较。
J Pharmacol Exp Ther. 1956 Nov;118(3):328-37.

受体阻断药物对苯丙胺所致脑糖原耗竭的影响。

Effect of receptor blocking drugs on the depletion of brain glycogen by amphetamine.

作者信息

Hutchins D A, Rogers K J

出版信息

Br J Pharmacol. 1971 Nov;43(3):504-13. doi: 10.1111/j.1476-5381.1971.tb07181.x.

DOI:10.1111/j.1476-5381.1971.tb07181.x
PMID:4400527
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1665784/
Abstract
  1. Amphetamine sulphate (5 mg/kg), administered intraperitoneally, reduces the concentration of glycogen in the mouse brain by 25-30% after 30 minutes.2. The effect of several receptor blocking drugs on the amphetamine-induced cerebral glycogenolysis was studied.3. DL-Propranolol (0.25 mg/kg) and pronethalol (10 mg/kg) antagonized the depletion of brain glycogen by amphetamine.4. Phentolamine, methysergide, atropine and mepyramine failed to antagonize the amphetamine-induced glycogenolysis.5. D-Propranolol, chlorpromazine and phenoxybenzamine antagonized the glycogenolytic effect of amphetamine only when administered in sedative doses.6. It is concluded that amphetamine-induced glycogenolysis in the mouse brain may be mediated through a beta-adrenoceptor.
摘要

  1. 硫酸苯丙胺（5毫克/千克）腹腔注射后30分钟，可使小鼠脑内糖原浓度降低25 - 30%。

  2. 研究了几种受体阻断药物对苯丙胺诱导的脑糖原分解的影响。

  3. DL-普萘洛尔（0.25毫克/千克）和丙萘洛尔（10毫克/千克）可拮抗苯丙胺引起的脑糖原消耗。

  4. 酚妥拉明、麦角酰二乙胺、阿托品和甲吡胺未能拮抗苯丙胺诱导的糖原分解。

  5. D-普萘洛尔、氯丙嗪和酚苄明仅在镇静剂量下给药时，才拮抗苯丙胺的糖原分解作用。

  6. 得出的结论是，苯丙胺诱导的小鼠脑内糖原分解可能通过β-肾上腺素能受体介导。