Tetsuguchi M, Yamashita Y, Katayama M, Sugawa-Katayama Y
Department of Food and Nutrition, Faculty of Human Life Science, Osaka City University, Japan.
J Nutr Sci Vitaminol (Tokyo). 1998 Oct;44(5):601-12. doi: 10.3177/jnsv.44.601.
We reported in the previous paper that rats fed a curdlan diet showed significant increases in the weight of the cecum and its contents, a decrease in fecal wet weight, a retardation in the transit time of the gastrointestinal tract and morphological changes of the ileal and cecal mucosal surface when compared with the rats fed a cellulose diet. In the present study, we intended to learn if the curdlan effects on the morphological structure of intestinal mucosa were reversible. When rats were fed on the curdlan diet for 2 weeks followed by a cellulose diet for another 2 weeks, the cecum and cecal contents were not different from those of the cellulose group. The transit time of the gastrointestinal tract of the curdlan-followed-by-cellulose group was shorter than that of the curdlan group, whereas it was longer than that of the cellulose group. In scanning electron micrographs, the ileal villi of the curdlan-followed-by-cellulose group were normal, as in the cellulose group. However, their ileal and cecal microvilli were similar to those of the curdlan group, that is, the microvilli were crowded and more tightly packed, and some appeared to have been squeezed out. From these results, it was concluded that the effects of the curdlan feeding were only partially reversible, but the effects on the surface structure of intestinal mucosa were still sustained even after curdlan feeding of 2 weeks was discontinued. This might result from response to the high viscosity of the intestinal contents remaining after discontinuation of the curdlan.
我们在上一篇论文中报道，与喂食纤维素饮食的大鼠相比，喂食可得然胶饮食的大鼠盲肠及其内容物重量显著增加，粪便湿重降低，胃肠道转运时间延长，回肠和盲肠黏膜表面出现形态学变化。在本研究中，我们旨在了解可得然胶对肠黏膜形态结构的影响是否可逆。当大鼠先喂食可得然胶饮食2周，然后再喂食纤维素饮食2周时，盲肠及盲肠内容物与纤维素组无差异。先喂食可得然胶后再喂食纤维素组的胃肠道转运时间比可得然胶组短，但比纤维素组长。在扫描电子显微镜照片中，先喂食可得然胶后再喂食纤维素组的回肠绒毛与纤维素组一样正常。然而，其回肠和盲肠微绒毛与可得然胶组相似，即微绒毛拥挤且排列更紧密，有些似乎被挤出。从这些结果可以得出结论，可得然胶喂养的影响只是部分可逆，即使在停止喂食可得然胶2周后，对肠黏膜表面结构的影响仍然存在。这可能是由于停止喂食可得然胶后肠道内容物的高粘度所引起的反应。
