Hodak E, Lapidoth M, David M
Department of Dermatology, Rabin Medical Center, Beilinson Campus, Petah Tiqva, Israel.
J Am Acad Dermatol. 1999 Jan;40(1):91-4. doi: 10.1016/s0190-9622(99)70533-5.
IgA pemphigus of the subcorneal pustular dermatosis (SPD) type is characterized by subcorneal acantholysis and by an abundance of neutrophils, making colchicine a reasonable pharmacologic option for treatment.
We attempted to determine the efficacy of colchicine in the treatment of SPD-type IgA pemphigus.
Two patients with SPD-type IgA pemphigus were treated with colchicine 1.5 mg/day as monotherapy.
A sustained clinical response was achieved within 2 to 3 weeks of therapy. Relapses were noted each time colchicine was stopped.
Colchicine should be considered in the treatment of SPD-type IgA pemphigus.
角层下脓疱性皮病（SPD）型IgA天疱疮的特征为角层下棘层松解和大量中性粒细胞，这使得秋水仙碱成为一种合理的治疗药物选择。
我们试图确定秋水仙碱治疗SPD型IgA天疱疮的疗效。
两名SPD型IgA天疱疮患者接受每日1.5毫克秋水仙碱单药治疗。
治疗2至3周内取得了持续的临床反应。每次停用秋水仙碱时均出现复发。
治疗SPD型IgA天疱疮时应考虑使用秋水仙碱。
