Bugat R, Walsh J H, Ippoliti A, Elashoff J, Grossman M I
Gastroenterology. 1976 Dec;71(6):1114-6.
Extracts were prepared from plasma of 12 subjects with normal serum gastrin concentration (less than 125 pg/ml), 5 normal subjects and 7 patients with duodenal ulcer and basal gastric acid hypersecretion (greater than 15 mEg/hr). Bioassays of plasma extracts were performed in anesthetized rats with perfused stomachs and acid out-puts were compared with those produced by normal saline and by 50 ng pentagastrin given in random order. Compared with saline, plasma extracts from 5 of 7 hypersecretor patients produced significant stimulation of acid secretion while none of the extracts from normal subjects produced acid stimulation. The stimulant identified in plasma from hypersecretor patients appears to be distinct from gastrin.
从12名血清胃泌素浓度正常（低于125 pg/ml）的受试者、5名正常受试者以及7名十二指肠溃疡且基础胃酸分泌过多（大于15 mEg/小时）的患者的血浆中提取样本。在麻醉且胃被灌注的大鼠身上对血浆提取物进行生物测定，并将酸分泌量与生理盐水以及随机给予的50 ng五肽胃泌素所产生的酸分泌量进行比较。与生理盐水相比，7名分泌过多患者中有5名的血浆提取物产生了显著的酸分泌刺激，而正常受试者的提取物均未产生酸分泌刺激。在分泌过多患者血浆中鉴定出的刺激物似乎与胃泌素不同。
