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一种可重复的急性出血性溃疡动物模型——“溃疡制造器”。

A reproducible animal model of acute bleeding ulcer-the "ulcer maker".

作者信息

Protell R L, Silverstein F E, Piercey J, Dennis M, Sprake W, Rubin C E

出版信息

Gastroenterology. 1976 Dec;71(6):961-4.

PMID:992279
Abstract

An instrument has been developed which creates an experimental model of an acute bleeding gastric ulcer. The diameter and depth of these gastric ulcers are reproducible. The instrument can be used endoscopically or at laparotomy. Using this ulcer model nonsurgical modalities for the treatment of upper gastrointestinal bleeding can be compared in a controlled manner. This standard experimental model may also facilitate comparison of results among different research groups.

摘要

已经开发出一种仪器,它能创建急性出血性胃溃疡的实验模型。这些胃溃疡的直径和深度是可重复的。该仪器可通过内镜使用或在剖腹手术时使用。利用这个溃疡模型,可以以可控的方式比较治疗上消化道出血的非手术方法。这个标准实验模型也可能有助于不同研究小组之间结果的比较。

相似文献

1
A reproducible animal model of acute bleeding ulcer-the "ulcer maker".一种可重复的急性出血性溃疡动物模型——“溃疡制造器”。
Gastroenterology. 1976 Dec;71(6):961-4.
2
Evaluation of Nd:YAG photocoagulation using a new experimental ulcer model with a single bleeding artery.使用具有单一出血动脉的新型实验性溃疡模型评估钕钇铝石榴石激光光凝术。
Gastroenterology. 1981 Jun;80(6):1522-7.
3
Control of upper gastrointestinal hemorrhage by endoscopic spraying of clotting factors.
Gastroenterology. 1979 Oct;77(4 Pt 1):642-6.
4
Computer-assisted electrocoagulation: bipolar vs. monopolar in the treatment of experimental canine gastric ulcer bleeding.计算机辅助电凝术:双极与单极在实验性犬胃溃疡出血治疗中的应用
Gastroenterology. 1981 Mar;80(3):451-5.
5
Endoscopic laser treatment. III. Development and testing of a gas-jet-assisted argon laser waveguide in control of bleeding experimental ulcers.内镜激光治疗。III. 用于控制实验性溃疡出血的气体喷射辅助氩激光波导的研发与测试。
Gastroenterology. 1978 Feb;74(2 Pt 1):232-9.
6
Developing an animal model of massive ulcer bleeding for assessing endoscopic hemostatic devices.建立用于评估内镜止血设备的大规模溃疡出血动物模型。
Endoscopy. 2005 Sep;37(9):847-51. doi: 10.1055/s-2005-870226.
7
[Yag laser photocoagulation and monopolar electrohydrocoagulation: randomized study of the hemostatic effect on experimental hemorrhagic ulcer in dogs].[钇铝石榴石激光光凝术与单极电水囊凝血术:对犬实验性出血性溃疡止血效果的随机研究]
Gastroenterol Clin Biol. 1985 Mar;9(3):212-9.
8
Randomized controlled study of 3 different types of hemoclips for hemostasis of bleeding canine acute gastric ulcers.三种不同类型的止血夹用于犬急性胃溃疡出血止血的随机对照研究。
Gastrointest Endosc. 2006 Nov;64(5):768-73. doi: 10.1016/j.gie.2006.06.031.
9
Comparison of endoscopic electrocoagulation and laser photocoagulation of bleeding canine gastric ulcers.犬出血性胃溃疡的内镜下电凝术与激光光凝术的比较
Gastroenterology. 1982 May;82(5 Pt 1):904-10.
10
Endoscopic plication of massively bleeding peptic ulcer by using the Eagle Claw VII device: a feasibility study in a porcine model.使用鹰爪七号装置对大量出血性消化性溃疡进行内镜折叠术:在猪模型中的可行性研究
Gastrointest Endosc. 2006 Apr;63(4):681-5. doi: 10.1016/j.gie.2005.10.030.

引用本文的文献

1
Creation of an effective and reproducible nonsurvival porcine model that simulates actively bleeding peptic ulcers.创建一种有效且可重复的非存活猪模型,用于模拟活动性出血性消化性溃疡。
Gastrointest Endosc. 2008 Sep;68(3):548-53. doi: 10.1016/j.gie.2008.03.1087. Epub 2008 Jul 11.
2
A randomised controlled comparison of injection, thermal, and mechanical endoscopic methods of haemostasis on mesenteric vessels.注射、热凝及机械性内镜下肠系膜血管止血方法的随机对照比较
Gut. 1998 Apr;42(4):462-9. doi: 10.1136/gut.42.4.462.
3
Iced saline lavage does not slow bleeding from experimental canine gastric ulcers.
冰盐水灌洗并不能减缓实验性犬胃溃疡的出血。
Dig Dis Sci. 1981 Dec;26(12):1065-8. doi: 10.1007/BF01295969.
4
Safety and efficacy of Neodymium-Yag laser photocoagulation: an experimental study in dogs.钕钇铝石榴石激光光凝术的安全性和有效性:犬类实验研究
Gut. 1981 Jan;22(1):38-44. doi: 10.1136/gut.22.1.38.
5
Nature and extent of histological changes induced by argon laser photocoagulation in canine gastric mucosa.氩激光光凝对犬胃黏膜诱导的组织学变化的性质和程度。
Gut. 1980 Dec;21(12):1047-55. doi: 10.1136/gut.21.12.1047.
6
NdYAG laser photocoagulation in the dog stomach.犬胃的NdYAG激光光凝术
Gut. 1980 Oct;21(10):818-25. doi: 10.1136/gut.21.10.818.
7
Endoscopic treatment of gastrointestinal bleeding. Topical therapy and variceal injection.胃肠道出血的内镜治疗。局部治疗和曲张静脉注射。
Dig Dis Sci. 1981 Jul;26(7 Suppl):44S-46S. doi: 10.1007/BF01300806.
8
Endoscopic bipolar electrocoagulation: development of a new bipolar coagulator for stopping gastrointestinal bleeding.
Gastroenterol Jpn. 1982 Apr;17(2):75-9. doi: 10.1007/BF02774543.
9
Endoscopic hemostasis using laser photocoagulation and electrocoagulation.使用激光光凝和电凝进行内镜止血。
Dig Dis Sci. 1981 Jul;26(7 Suppl):31S-40S. doi: 10.1007/BF01300804.
10
Control of upper gastrointestinal bleeding with a microcrystalline collagen hemostat.使用微晶胶原止血剂控制上消化道出血。
Dig Dis Sci. 1982 Nov;27(11):981-5. doi: 10.1007/BF01391743.