Bown S G, Salmon P R, Storey D W, Calder B M, Kelly D F, Adams N, Pearson H, Weaver B M
Gut. 1980 Oct;21(10):818-25. doi: 10.1136/gut.21.10.818.
Considerable discussion still centres around the relative merits of the Argon and Neodymium Yttrium Aluminum Garnet (NdYAG) lasers for the endoscopic treatment of gastrointestinal haemorrhage, although both are undoubtedly effect. We have carried out experiments to elucidate which factors determine the safety and efficacy of NdYAG laser photocoagulation. Histological studies on normal gastric mucosa showed that the depth of tissue damage depended mainly on the total incident laser energy, whereas the effectiveness of photocoagulation of induced gastric ulcers in heparinised animals depended on the laser power and the exposure time used. Optimum haemostasis with minimum tissue damage was obtained using pulses of 300 to 500 ms duration with energies of 25 to 40 J. We consider these parameters safe and effective for use in pilot clinical studies.
尽管氩激光和钕钇铝石榴石（NdYAG）激光在内镜治疗胃肠道出血方面无疑都有效果，但关于它们相对优缺点的讨论仍相当多。我们进行了实验以阐明哪些因素决定NdYAG激光光凝的安全性和有效性。对正常胃黏膜的组织学研究表明，组织损伤深度主要取决于总入射激光能量，而在肝素化动物中诱导胃溃疡的光凝效果则取决于激光功率和使用的照射时间。使用持续时间为300至500毫秒、能量为25至40焦耳的脉冲可实现最佳止血且组织损伤最小。我们认为这些参数用于初步临床研究是安全有效的。
