O'Keefe M, O'Reilly J, Lanigan B
Children's Hospital, Temple Street, Dublin, Ireland.
Br J Ophthalmol. 1998 Nov;82(11):1246-8. doi: 10.1136/bjo.82.11.1246.
Visual outcome of 66 eyes in 37 patients who had undergone treatment with either cryotherapy or diode laser for threshold retinopathy of prematurity was assessed.
17 patients, representing 30 eyes treated with cryotherapy, were examined at between 56 and 98 months corrected age (median 68 months). 20 patients representing 36 eyes treated with diode laser, were examined at between 30 and 66 months corrected age (median 51 months). Structural outcome was categorised as: optimal--flat posterior pole; suboptimal--macular ectopia, optic nerve hypoplasia, retinal fold involving the macula, and retinal detachment involving the macula.
Optimal structural outcome was, in the absence of amblyopia, associated with optimal visual acuity (of 6/12 or better) in all cases, with most eyes achieving a visual acuity of 6/9 or 6/6. Suboptimal structural outcome was invariably associated with suboptimal visual acuity. Amblyopia was present in eight out of 20 cryotherapy treated eyes and in five out of 26 laser treated eyes with an optimal structural outcome. Refractive errors were significantly less in laser treated eyes as was the incidence of anisometropic amblyopia.
Eyes treated with either cryotherapy or diode laser for threshold retinopathy of prematurity with optimal structural outcome are associated with development of optimal visual acuity--that is, 6/12 or better. Treatment with either cryotherapy or laser does not in itself reduce the visual potential of these eyes.
评估37例接受冷冻疗法或二极管激光治疗阈值早产儿视网膜病变的患者中66只眼的视觉预后。
17例接受冷冻疗法治疗的30只眼的患者,在矫正年龄56至98个月(中位数68个月)时接受检查。20例接受二极管激光治疗的36只眼的患者,在矫正年龄30至66个月(中位数51个月)时接受检查。结构预后分为:最佳——扁平后极;次佳——黄斑异位、视神经发育不全、累及黄斑的视网膜褶皱以及累及黄斑的视网膜脱离。
在没有弱视的情况下,最佳结构预后与所有病例的最佳视力(6/12或更好)相关,大多数眼睛的视力达到6/9或6/6。次佳结构预后总是与次佳视力相关。在20只接受冷冻疗法治疗且结构预后最佳的眼中,有8只存在弱视;在26只接受激光治疗且结构预后最佳的眼中,有5只存在弱视。激光治疗的眼睛屈光不正明显较少,屈光参差性弱视的发生率也较低。
接受冷冻疗法或二极管激光治疗阈值早产儿视网膜病变且结构预后最佳的眼睛,其视力发育为最佳视力,即6/12或更好。冷冻疗法或激光治疗本身并不会降低这些眼睛的视觉潜能。