单独使用苯并恶嗪诺利福霉素KRM-1648或与半量分泌型白细胞蛋白酶抑制剂或非甾体抗炎药双氯芬酸钠联合使用对小鼠鸟分枝杆菌复合群感染的治疗效果。
Therapeutic effects of benzoxazinorifamycin KRM-1648 administered alone or in combination with a half-sized secretory leukocyte protease inhibitor or the nonsteroidal anti-inflammatory drug diclofenac sodium against Mycobacterium avium complex infection in mice.
作者信息
Sano C, Shimizu T, Sato K, Kawauchi H, Kawahara S, Tomioka H
机构信息
Department of Microbiology and Immunology, Shimane Medical University, Japan.
出版信息
Antimicrob Agents Chemother. 1999 Feb;43(2):360-4. doi: 10.1128/AAC.43.2.360.
Abstract
The effects of half-sized secretory leukocyte protease inhibitor or diclofenac sodium administered alone or in combination with the benzoxazinorifamycin KRM-1648 on the therapeutic efficacy of KRM-1648 against Mycobacterium avium complex (MAC) in mice were studied. Neither of the two anti-inflammatory drugs affected the efficacy of KRM-1648, while they exerted significant modulating effects on tumor necrosis factor alpha production by MAC-infected macrophages.
摘要
研究了单独给予或与苯并恶嗪诺利福霉素KRM - 1648联合给予半量分泌型白细胞蛋白酶抑制剂或双氯芬酸钠对KRM - 1648抗小鼠鸟分枝杆菌复合群（MAC）治疗效果的影响。这两种抗炎药均未影响KRM - 1648的疗效，但它们对MAC感染的巨噬细胞产生肿瘤坏死因子α具有显著的调节作用。
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