一种用于比较隐球菌性脑膜炎治疗方法的替代动物模型。
An alternative animal model for comparison of treatments for cryptococcal meningitis.
作者信息
Najvar L K, Bocanegra R, Graybill J R
机构信息
Veterans Administration Hospital, San Antonio, Texas, USA.
出版信息
Antimicrob Agents Chemother. 1999 Feb;43(2):413-4. doi: 10.1128/AAC.43.2.413.
Abstract
Weanling outbred rats were infected with Cryptococcus neoformans by direct percranial puncture and inoculation into the cranium. A lethal infection ensued. Treatment with LY295337, a depsipeptide with antifungal activity, was effective in prolonging survival and reducing fungal counts in brain tissue. Weanling rats are an acceptable model for the study of central nervous system infection with C. neoformans.
摘要
通过直接经颅穿刺并将新型隐球菌接种到颅骨内，使断奶的远交系大鼠感染新型隐球菌。随后发生了致命感染。用具有抗真菌活性的缩肽LY295337进行治疗，可有效延长生存期并减少脑组织中的真菌数量。断奶大鼠是研究新型隐球菌中枢神经系统感染的合适模型。
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