Giuliana G, Pizzo G, Milici M E, Giangreco R
Department of Periodontology, School of Dentistry, University of Palermo, Italy.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1999 Jan;87(1):44-9. doi: 10.1016/s1079-2104(99)70293-3.
Antimicrobial mouthrinses may represent a valid alternative to topical antifungal agents. However, the action of antimicrobials could be affected by the different ingredients incorporated into mouthrinse products. The purpose of the present study was to investigate the in vitro antifungal and fungicidal activities of antimicrobials alone.
A broth macrodilution method was used to determine the minimum inhibitory concentration of 4 antimicrobial agents against Candida species. Minimum fungicidal concentration was also determined.
All antimicrobials showed antifungal activity against all tested organisms, but cetylpyridinium chloride received significantly lower minimum inhibitory concentrations (P < .005). Cetylpyridinium chloride also showed a greater fungicidal activity than chlorhexidine digluconate and hexetidine (P< .005), whereas sanguinarine chloride appeared to be less fungicidal against most of the isolates tested.
These findings suggest that cetylpyridinium chloride may be used as a topical antifungal agent. Clinical trials are now required to assess its value in the management of oral candidosis.
抗菌漱口水可能是局部抗真菌药物的有效替代品。然而，抗菌剂的作用可能会受到漱口水产品中不同成分的影响。本研究的目的是单独研究抗菌剂的体外抗真菌和杀菌活性。
采用肉汤稀释法测定4种抗菌剂对念珠菌属的最低抑菌浓度。还测定了最低杀菌浓度。
所有抗菌剂对所有受试微生物均表现出抗真菌活性，但西吡氯铵的最低抑菌浓度显著较低（P <.005）。西吡氯铵的杀菌活性也高于葡萄糖酸氯己定和己脒定（P<.005），而氯化血根碱对大多数受试分离株的杀菌活性似乎较低。
这些发现表明西吡氯铵可用作局部抗真菌剂。目前需要进行临床试验以评估其在口腔念珠菌病治疗中的价值。
