Mishra Rahul, Tandon Shobha, Rathore Monika, Banerjee Molay
Assistant Professor, Department of Dentistry, UP Rural Institute of Medical Sciences and Research, Saifai, Uttar Pradesh, India.
Ex-Dean, Department of Pedodontics and Preventive Dentistry, Babu Banarasi Das College of Dental Sciences, Lucknow, Uttar Pradesh, India.
Int J Clin Pediatr Dent. 2016 Jan-Mar;9(1):25-30. doi: 10.5005/jp-journals-10005-1328. Epub 2016 Apr 22.
A growing number of dentists are embracing the philosophy that natural agents are better for children's oral health. Knowledge of probiotics on host immune system has entered a new phase of research, and progression in this field is likely to offer novel means by modulating host immunity for prevention and treatment of a wide variety of oral diseases.
To compare the antimicrobial efficacy of probiotics in reducing salivary Candida albicans counts with commonly used antimicrobial agents like 0.2% chlorhexidine and herbal rinse.
A randomized clinical trial was conducted on 60 subjects aged between 6 and 14 years, for a period of 9 months. The subjects were randomly divided into three groups comprising 20 subjects in each group. Three oral agents were administered twice daily for a maximum period of 1 week. Candida albicans counts were recorded before and after intervention and the results were submitted for statistical analysis using Statistical Package for the Social Sciences (SPSS) version 15.0 software.
The change in mean log10 colony-forming unit (CFU)/ ml of C. albicans in groups A to C was 0.43 ± 0.72, 0.68 ± 1.05 and 0.22 ± 0.66 CFU/ml respectively.
Data obtained from the study demonstrated that probiotic rinse was equally effective as 0.2% chlorhexidine digluconate rinse in reducing C. albicans counts after 1 week of intervention. Herbal oral rinse was least effective. Probiotic oral rinses have opened new horizons in improvement of oral health by maintaining healthy ecosystem. However, a longitudinal study with larger sample size needs to be undertaken to evaluate the therapeutic effects of probiotics and herbal agents. How to cite this article: Mishra R, Tandon S, Rathore M, Banerjee M. Antimicrobial Efficacy of Probiotic and Herbal Oral Rinses against Candida albicans in Children: A Randomized Clinical Trial. Int J Clin Pediatr Dent 2016;9(1):25-30.
越来越多的牙医秉持天然制剂对儿童口腔健康更有益的理念。益生菌对宿主免疫系统的研究已进入一个新的阶段，该领域的进展可能会通过调节宿主免疫力为预防和治疗多种口腔疾病提供新方法。
比较益生菌与常用抗菌剂（如0.2%氯己定和草药漱口水）在降低唾液中白色念珠菌数量方面的抗菌效果。
对60名年龄在6至14岁之间的受试者进行了一项为期9个月的随机临床试验。受试者被随机分为三组，每组20名。三种口腔制剂每天服用两次，最长服用1周。在干预前后记录白色念珠菌数量，并使用社会科学统计软件包（SPSS）15.0版软件对结果进行统计分析。
A组至C组白色念珠菌每毫升平均log10菌落形成单位（CFU）的变化分别为0.43±0.72、0.68±1.05和0.22±0.66 CFU/ml。
研究获得的数据表明，干预1周后，益生菌漱口水在降低白色念珠菌数量方面与0.2%葡萄糖酸氯己定漱口水同样有效。草药口腔漱口水效果最差。益生菌口腔漱口水通过维持健康的生态系统为改善口腔健康开辟了新的前景。然而，需要进行一项样本量更大的纵向研究来评估益生菌和草药制剂的治疗效果。如何引用本文：米什拉R、坦登S、拉托尔M、班纳吉M。益生菌和草药口腔漱口水对儿童白色念珠菌的抗菌效果：一项随机临床试验。《国际临床儿科牙科学杂志》2016年；9（1）：25 - 30。
