Said S I, Raza S, Berisha H I
Department of Veterans Affairs Medical Center, Northport, New York, USA.
Ann N Y Acad Sci. 1998 Dec 11;865:582-5. doi: 10.1111/j.1749-6632.1998.tb11240.x.
(1) A beta peptides potentiate vasoconstriction, caused by norepinephrine, and possibly other endogenous vasoconstrictors. If this potentiation occurs in the cerebral circulation, close to sites of A beta deposition in AD brains, the enhanced vasoconstriction could result in neuronal ischemia and death. (2) By neutralizing this deleterious effect of A beta, and through other neuroprotective mechanisms, VIP may provide an important defense against neuronal loss in AD.
