Sata T, Misra H P, Kubota E, Said S I
Peptides. 1986;7 Suppl 1:225-7. doi: 10.1016/0196-9781(86)90190-7.
Vasoactive intestinal polypeptide (VIP) is a potent endogenous vasodilator. VIP-induced vasodilation is independent of adrenergic or cholinergic receptors and, for the most part, of arachidonate metabolites, but its mechanism is still unknown. In view of the recently demonstrated essential role of endothelium in the relaxant effect of numerous vasodilators, we have investigated the importance of endothelium in the vascular relaxation induced by VIP. Vascular smooth muscle preparations were circular strips of the pulmonary artery of guinea pig, rat and rabbit, and rat thoracic aorta, previously contracted by a synthetic prostaglandin endoperoxide analog. VIP relaxed pulmonary artery of all species by an endothelium-independent mechanism, but relaxed rat thoracic aorta only in the presence of intact endothelium.
血管活性肠肽（VIP）是一种强效的内源性血管舒张剂。VIP诱导的血管舒张独立于肾上腺素能或胆碱能受体，并且在很大程度上独立于花生四烯酸代谢产物，但其机制仍不清楚。鉴于最近已证明内皮细胞在多种血管舒张剂的舒张作用中起重要作用，我们研究了内皮细胞在VIP诱导的血管舒张中的重要性。血管平滑肌制备物是豚鼠、大鼠和兔的肺动脉以及大鼠胸主动脉的环形条带，先前已用合成前列腺素内过氧化物类似物使其收缩。VIP通过不依赖内皮细胞的机制使所有物种的肺动脉舒张，但仅在完整内皮细胞存在的情况下使大鼠胸主动脉舒张。
