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[细胞色素c在预防复苏后中枢神经系统功能障碍中的作用]

[The role of cytochrome c in preventing postresuscitation functional disorders of the central nervous system].

作者信息

Boiarinov G A, Mukhina I V, Penknovich A A, Snopova L B, Iakovleva E I, Balandina M V, Zimin Iu V, Prodanets N N

机构信息

Central Research Laboratory, Nizhni Novgorod Medical Academy, Russia.

出版信息

Eksp Klin Farmakol. 1998 Nov-Dec;61(6):54-7.

PMID:9929820
Abstract

The effect of intracarotid injection of cytochrome c on the course of the early postresuscitation period was studied in experimental animals (albino rats) after 5-min clinical death from acute blood loss. It was shown that the drug normalizes the disturbed metabolic processes in the brain, reduces the structural changes consequent upon total ischemia, stabilizes the activity of the cardiovascular system and, as a result of this, contributes to restoration of functional activity of the central nervous system in the early postresuscitation period.

摘要

在实验动物(白化大鼠)因急性失血导致5分钟临床死亡后,研究了颈内注射细胞色素c对复苏后早期病程的影响。结果表明,该药物可使大脑中紊乱的代谢过程恢复正常,减少完全缺血后随之而来的结构变化,稳定心血管系统的活性,并因此有助于在复苏后早期恢复中枢神经系统的功能活动。

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