Verbeeck W J, Berk M
Department of Psychiatry, University of the Witwatersrand Medical School, Johannesburg, South Africa.
Pharmacopsychiatry. 1998 Nov;31(6):236-7. doi: 10.1055/s-2007-979335.
Both diarrhea and colitis associated with clozapine have been reported. We present a case of clozapine-associated neutropenia complicated by cytomegalovirus colitis. The definitive diagnosis was suggested on biopsy which showed eosinophilic intranuclear inclusions suggestive of cytomegalovirus infection, and confirmed on immunohistochemistry. Neutropenia or agranulocytosis in association with clozapine treatment may be complicated by colitis. In such cases, investigations for cytomegalovirus may be indicated.
已有报道称氯氮平会引发腹泻和结肠炎。我们报告了一例氯氮平相关性中性粒细胞减少症并发巨细胞病毒性结肠炎的病例。活检提示了明确诊断，活检显示嗜酸性核内包涵体提示巨细胞病毒感染，并经免疫组化确诊。氯氮平治疗相关的中性粒细胞减少症或粒细胞缺乏症可能并发结肠炎。在这种情况下，可能需要进行巨细胞病毒检查。
