Nizato T, Koeda T, Tsuruoka T, Inouye S, Niida T
J Antibiot (Tokyo). 1976 Aug;29(8):833-40. doi: 10.7164/antibiotics.29.833.
The nephrotoxicity of rats caused by dibekacin (3',4'-dideoxykanamycin B) or kanamycin with or without dextran was effectively reduced by D-glucaro-delta-lactam potassium salt, as evidenced by lower levels of blood urea nitrogen and kidney edema rate, better excretion of antibiotics,and less morphological damage. Protection was dosage related, and potentiated with increasing doses, but only when the two drugs were given simultaneously. Among three alkali-metal salts examined, the potassium salt was almost equal to the lithium salt, but surpassed the sodium salt in effectiveness. Inorganic salts, in particular potassium chloride were found to be effective for the protection of normal rats, but their effect decreased for the dehydrated rats, especially in the presence of dextran.
D - 葡糖醛酸 - δ - 内酯钾盐可有效降低由双去氧卡那霉素B（地贝卡星）或卡那霉素单独或与葡聚糖联合使用所引起的大鼠肾毒性，这可通过较低的血尿素氮水平、较低的肾脏水肿率、较好的抗生素排泄情况以及较少的形态学损伤得以证明。保护作用与剂量相关，且随着剂量增加而增强，但仅在两种药物同时给药时才会如此。在所研究的三种碱金属盐中，钾盐的效果几乎与锂盐相当，但在有效性方面超过钠盐。已发现无机盐，尤其是氯化钾，对正常大鼠具有保护作用，但对脱水大鼠的作用减弱，特别是在存在葡聚糖的情况下。
